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Billing code

G381A — Standard Chemotherapy - Agents With Minor Toxicity That Require Physician Monitoring, Including Any Additional Standard Chemotherapy Other Than The Initial Agent

Standard chemotherapy

Bill G381 for supervised IV chemotherapy with minor-toxicity agents, such as methotrexate or fluorouracil, including extra standard agents.

Watch for: It includes all assessments by any physician for the next 24 hours, plus venipuncture and line placement.

Code

G381A

Description

Standard Chemotherapy - Agents With Minor Toxicity That Require Physician Monitoring, Including Any Additional Standard Chemotherapy Other Than The Initial Agent

FHO+ basket

Covered by the FHO+ base rate payment for enrolled patients, and shadow billed at 30% (50% for Schedule 2B procedures).

Effective date

Apr 1, 2026

Termination date

No end date

Explanation

Updated October 26, 2026

Standard chemotherapy: IV agents with minor toxicity that need physician monitoring, including extra standard agents after the first.

What it covers

G381 is physician-supervised IV chemotherapy (drug therapy for malignant or autoimmune disease) with agents of minor toxicity that need physician monitoring, including any additional standard agent beyond the first (J57).

Examples include cyclophosphamide, methotrexate, fluorouracil, leucovorin and zoledronic acid (J57). Complex agents are G345 and special agents G359 (J57).

Billing rules

• Payable only for biologic agents that are monoclonal antibodies or cytokines; blood products, insulin and vaccines are not biologic agents for this purpose (J57).
• Includes venipuncture, any vascular access line and giving the agent(s) (J57).
• Includes all patient assessments by any physician for 24 hours after the treatment (J57).
• The physician must be available to intervene promptly at the start and for the whole therapy to manage immediate and delayed toxicities (J57).
• G381 is the exception to the rule that injections into an established IV apparatus can't be claimed (J55).
• Marked (+): add G700 when it is the sole reason for the visit (J57, J3).

Often billed with

• G700 when G381 is the only reason for the visit (J3).

Related codes: G345, G359, G382, G388, G075, G390, G700

Source: Schedule of Benefits (July 1, 2026), Diagnostic and Therapeutic Procedures, Injections or Infusions (Chemotherapy), page J57.

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